VAXXITEK® HVT + IBD Efficacy, Safety, & Health Benefits of Disease Reduction

Protection against two significant, immunosuppressive viral diseases in poultry

  • VAXXITEK HVT + IBD is indicated to aid in the prevention of Marek's disease and infectious bursal disease (IBD; also known as Gumboro disease)*
  • The vaccine uses the turkey herpesvirus (HVT), which is long-established to stimulate immunity against Marek's disease, plus a protein from the IBD virus to stimulate immunity against IBD

Scientific evidence of global protection

In more than 65+ scientific papers published to date (see all), VAXXITEK HVT + IBD induced clinical protection against a variety of different pathotypes of the IBD virus found worldwide, including classic, variant, and very virulent strains.* It has been used to help prevent IBD and Marek's disease on every continent in the world.

Effective in all types of production chickens

All types of poultry businesses can use VAXXITEK HVT + IBD—it is effective in healthy broiler, layer, and breeder chickens.*

A single dose for early protection

Young chickens are most susceptible to infection by IBD and Marek’s viruses, so early protection is important.

  • Because of its underlying technology and mode of action, VAXXITEK HVT + IBD can be administered early—subcutaneously to healthy day-old chicks or in-ovo (at 18-19 days of incubation)
  • Early hatchery administration means VAXXITEK HVT + IBD can induce an immune responsebefore the riskiest periods for viral exposure; several published studies have shown reduced opportunity for an immunity gap as maternal antibodies decline:11-12, 18-19
    • IBD protection developing within seven12 to 14 days33
    • Marek's disease protection by 5 days*

Excellent safety that preserves the bursa

In several published studies, it was demonstrated that birds vaccinated with VAXXITEK HVT + IBD at one day of age maintained integrity of the bursa of Fabricius, thus experiencing no gross bursal lesions and negligible microscopic   lesions.10-12

Stronger overall immune foundation

  • VAXXITEK HVT + IBD helps protect against IBD, including both the clinical signs of the disease such as mortality, hemorrhage, and bursal atrophy as well as the "unseen" damage of immunosuppression associated with IBD that leads to poor performance and economic loss16-17
  • Published research has demonstrated that by preventing IBD and Marek’s disease, VAXXITEK HVT + IBD helps lay a strong foundation for chickens' immune health that makes them more resistant to other infectious diseases and more responsive to other important vaccines5-8, 13-15, 31
  • Our Veterinary Services group can customize a vaccination program for poultry businesses based on the use of VAXXITEK HVT + IBD to establish a strong immune foundation

Stimulates immunity against IBD and Marek's disease, with research demonstrating preservation of bursal integrity10-12 ...

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Referenced Publications

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1. Fernandez R, Rojo F, Garcia H, Sanchez P, Martinez H, Menendez A, Ruiz H et al. Field efficacy in broiler chickens in Latin America of vHVT-013, a Marek’s HVT vector vaccine expressing VP2 in infectious bursal disease virus. Oral presentation and abstract at the 15th congress of the World Veterinary Poultry Association, 2007; p199.

2. Atienza JC, Nagera AJ, Martinez PO, Baysac ND, Castillo MT, Damaso VR, Lemière S. Evaluation of a herpesvirus of turkey vector vaccine inducing protection against infectious bursal and Marek’s diseases (VAXXITEK® HVT+IBD) under Philippines field conditions. Oral presentation. XXIII World Poultry Congress, Brisbane, Australia. 2008. Article wpc0801684, 9 p.

3. Garritty AT. The eff ect of vectored HVT+IBD (Vaxxitek® HVT + IBD) vaccination on body weights, uniformity and virus shedding in commercial broilers. Abstract. International Poultry Scientifi c Forum, Atlanta, 2011; p31.

4. Godinho E, Pereira CJ, Fernandez A, Lemiere S. Case study of broiler chicken carcass condemnation in Brazil – Improved control using a herpesvirus turkey-infectious bursal disease (HVT-IBD) vector vaccine. Oral presentation. XVIIth Congress of the World Veterinary Poultry Association, Cancun, Mexico, 2011.

5. Hoerr FJ. Clinical Aspects of Immunosuppression in Poultry. Avian Dis., 2010; 54:2-15.

6. Naqi S, Thompson G, Bauman B, Mohammed H. The Exacerbating Effect of Infectious Bronchitis Virus Infection on the Infectious Bursal Disease Virus-Induced Suppression of Opsonization by Escherichia coli Antibody in Chickens. Avian Dis., 2001; 45:52-60.

7. Alonso Castro M, Merino Cabria D, Fernandez Garcia D, Torrubia Diaz J, Herreras Viejo R, Fernandez Revuelta J, Mateo Oyague J, Carvajal Uruena A. Evaluation of the effects of vaccination with a HVT-IBD vector vaccine on bursa Fabricii, production parameters and meat properties in broilers. Abstract. XVIIIth Congress of the World Veterinary Poultry Association, Nantes, France, 2013; in-press.

8. Devaud I, Herin JB, Trotel A, Pagot E, Voisin F. A field study in commercial layers to evaluate the effects of an HVT-IBD vector vaccine on production performances in comparison with a live IBD vaccine. Abstract. XVIIIth Congress of the World Veterinary Poultry Association, Nantes, France, 2013; in-press.

9. Lemiere S, Gauthier J.C., Kodjo A., Vinit L., Delvecchio A., Prandini F. Evaluation of the Protection against Infectious Bursal Disease (IBD) Challenge in Progeny Born to Parents Having Received a Vaccination Program Using Herpesvirus of Turkey-Infectious Bursal Disease (HVT-IBD) Vector Vaccine. World J. Vaccines, 2013; 3:46-51.

10. Goutebroze S, Curet M, Jay ML, Roux C, Le Gros F-X. Efficacy of a recombinant vaccine HVT-VP2 against Gumboro disease in the presence of maternal antibodies. British Poultry Science, 2003;44:824-825.

11. Massi P, Tosi G, Fiorentini L. Experimental challenge trial with a «very virulent» strain of Infectious Bursal Disease virus (vvIBDV) in commercial pullets vaccinated with an IBD vectored vaccine or with three different modified live vaccines. Zootecnica International, November 2008;50-57.

12. Bublot M, Pritchard N, Le Gros F-X, Goutebroze S. Use of a vectored vaccine against infectious bursal disease of chickens in the face of high-titred maternally derived antibody. Journal of Comparative Pathology, 2007;137:81-84.

13. Ganapathy K, Wilkins M, Forrester A, Jones RC, Lemiere S. Protection and immune responses against virulent infectious bronchitis viruses in HVT-IBD recombinant or IBD-complex vaccinated broiler chicks. Abstract. 1st International Respiratory Disease Conference, Athens, United States of America, 2011; p15.

14. Lemiere S, Wilkins M, Forrester A, Jones R, Ganapathy K. Protection and immune responses against virulent infectious bronchitis (IB) viruses in herpesvirus turkey-infectious bursal disease (HVT-IBD) vaccinated broiler chicks. Poster presentation. XVIIth Congress of the World Veterinary Poultry Association, Cancun, Mexico, 2011.

15. Rautenschlein S, Lemiere S, Prandini F. Evaluation of the effects of an HVT-IBD vector vaccine on the immune system of layer pullets in comparison with two commercial live IBD vaccines. Abstract. XVIIIth Congress of the World Veterinary Poultry Association, Nantes, France, 2013; in-press.

16. Rosenberger JK, Cloud SS. Identification and characterization of variant infectious bursal disease variant viruses. Journal of American Veterinary Medicine Association, 1986;189:357.

17. Cheville NF. Studies on the pathogenesis of Gumboro disease in the bursa of Fabricius, spleen and thymus of the chicken. American Journal of Pathology, 1967;51:527-551.

18. Le Gros F-X, Dancer A, Giacomini C, Pizzoni L, Bublot M, Graziani M, Prandini F. Field efficacy trial of a novel HVT-IBD vector vaccine for 1 day-old broilers. Vaccine, 2009;27:592-596.

19. Prandini F, Bublot M, Le Gros F-X, Dancer A, Pizzoni L, Lamichhane C. Assessment of the immune response in broilers and pullets using two ELISA lits after in ovo or day-old vaccination with a vectored HVT+IBD vaccine (VAXXITEK HVT+IBD). Zootecnica International, September 2008;40-50.

20. Lemiere S, Wong YS, Saint-Gerand AL, Goutebroze S, le Gros FX. Compatibility of Turkey Herpesvirus–Infectious Bursal Disease Vector Vaccine with Marek’s Disease Rispens Vaccine Injected into Day-Old Pullets. Avian Dis., 2011; 55:113-118.

21. Richard-Mazet A, Goutebroze S, Duboeuf M, Le Gros FX, Lemiere S, Bublot M. Compatibility of fowlpox-avian influenza and herpesvirus of turkey-infectious bursal disease vector vaccines injected in ovo to embryonated chicken eggs. Article. XVIIth Congress of the World Veterinary Poultry Association, Cancun, Mexico, 2011; p852-857.

22. Jay ML, Bizzini S, Duboeuf M, Goutebroze S, Le-Gros FX. Compatibility of a novel vector vaccine HVT-Gumboro with Newcastle and infectious bronchitis vaccination at one day of age. Abstract. 16th congress of the World Veterinary Poultry Association, Marrakesh, Morocco, 2009; p341.

23. Lemiere S, Fernandez R, Pritchard N, Cruz-Coy J, Rojo F, Wong SY, Saint-Gerand AL, Gauthier JC, Perozo F. Concomitant Turkey Herpesvirus–Infectious Bursal Disease Vector Vaccine and Oil-Adjuvanted Inactivated Newcastle Disease Vaccine Administration: Consequences Compatibility of Turkey Herpesvirus–Infectious Bursal Disease. Avian Dis., 2011; 55:642-649.

24. Botero LA, Fernandez R, Rojo F, Orrego JC, Lemiere S. Colombian chicken meat industry performance further to the use of VAXXITEK HVT+IBD vector vaccine. Oral presentation. 16th congress of the World Veterinary Poultry Association, Marrakesh, Morocco, 2009; p169.

25. Körösi L, Povazsan J, Penzes L, Sari I. Field results of VAXXITEK HVT+IBD vaccination in coloured birds in Hungary. Poster. 16th congress of the World Veterinary Poultry Association, Marrakesh, Morocco, 2009; p339.

26. Tang SF, He SJ, Li WM, Lemiere S. Field experience of vaccination in day-old broiler chickens with a herpesvirus turkey-infectious bursal disease (HVT-IBD) vector vaccine in different systems of chicken production across China. Poster presentation. XVIIth Congress of the World Veterinary Poultry Association, Cancun, Mexico, 2011; p920-926.

27. Herrmann A, Negm H, Sultan H. Turkey herpesvirus infectious bursal disease (HVT-IBD) vector vaccine – Field experience in commercial broilers in Egypt. Article. XVIIth Congress of the World Veterinary Poultry Association, Cancun, Mexico, 2011; p556-563.

28. Ochoa R. Monitoring of safety and efficacy of a herpesvirus turkey-infectious bursal disease (HVT-IBD) in a commercial layer operation in Mexico. Article. XVIIth Congress of the World Veterinary Poultry Association, Cancun, Mexico, 2011; p770-774.

29. Korosi L, Povazsan J, Sari I, Penzes L. Comparative field study of the Vaxxitek® HVT-IBD vaccine in commercial layer flocks. Article. XVIIth Congress of the World Veterinary Poultry Association, Cancun, Mexico, 2011; p644-650.

30. Lemiere S, Rojo R, He S, Tang S, Li W, Herrmann A, Prandini F. Benefits of the Herpesvirus of Turkey vector vaccine of Infectious Bursal Disease in control of immune-depression in broilers and decrease of use of antibiotic medication. Abstract. XVIIIth Congress of the World Veterinary Poultry Association, Nantes, France, 2013; in-press.

31. Rautenschlein S, Lemiere S, Simon B, Prandini F. A comparison of the effects on the humoral and cell-mediated immunity between an HVT-IBD vector vaccine and an IBDV immune complex vaccine after in ovo vaccination of commercial broilers. Article. XVIIth Congress of the World Vet.

32. Lemiere S, Bublot M, de Saint-Vis B, Le-Gros FX, Dancer A, Bollart A, Carlotti A. Validation of VAXXITEK HVT+IBD vaccine intake in chickens using vHVT13-specifi c qPCR by processing different tissue samples. Oral presentation. 16th congress of the World Veterinary Poultry Association, Marrakesh, Morocco, 2009; p165.

33. Rautenschlein S, Simon B, Jung A, Pöppel M, Prandini F, Lemiere S. Protective efficacy of VAXXITEK HVT + IBD in commercial layers and broilers against challenge with very virulent infectious bursal disease virus. 16th congress of the World Veterinary Poultry Association, Marrakesh, Morocco, 2009.

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